pentobarbital will lessen the extent or impact of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital boosts effects of ifosfamide by impacting hepatic enzyme CYP2B6 metabolism. Use Caution/Watch. Coadministration of ifosfamide with CYP2B6 inducers may increase metabolism of ifosfamide to its metabolite. Watch for greater effects/toxicities if put together with CYP2B6 inducers.
With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
pentobarbital will lower the level or influence of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers can result in reduced serum concentrations and loss of antimalarial efficacy
Estradiol valerate/dienogest should not be applied for a minimum of 28 days just after discontinuation from the inducer on account of risk of lessened contraceptive efficacy.
pentobarbital will minimize the level or result of fentanyl intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers may lead to the minimize in fentanyl plasma concentrations, insufficient efficacy or, potentially, growth of the withdrawal syndrome within a patient that has made Actual physical dependence to fentanyl.
pentobarbital will lower the extent or result of verapamil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will improve the level or outcome of clopidogrel by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will minimize the level or impact of zonisamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Mysterious.
Aged or debilitated people may possibly react to barbiturates with marked depression, exhilaration, and confusion; in certain clients, barbiturates regularly make pleasure in lieu of despair
pentobarbital will lessen the level or result of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with a solid CYP3A inducer decreases duvelisib space beneath the curve (AUC), which may lessen duvelisib efficacy.
pentobarbital will reduce the extent or result of rabeprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.
Barbiturates can induce hepatic microsomal enzymes causing greater metabolism and lowered anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); individuals stabilized check here on anticoagulant therapy may perhaps call for dosage changes if barbiturates are included to or withdrawn from their dosage regimen
pentobarbital will minimize the extent or impact of paclitaxel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.